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Most compounds that target tumor metabolism (methotrexate, 5-fluorouracil) fail to distinguish between tumor tissue and rapidly differentiating epithelial tissue (skin, bone marrow), 4,322 whereas therapies targeting the specific amino acid dependence of tumor cells are cell-selective, such as leukemic blasts that are selectively dependent on Asn, the use of bacterial-derived ASNase in pediatric ALL has significantly improved the cure rate

At the very low end of the Anela protocol (100 mcg/day for 10 days = 1 mg per cycle), its 100x less

Cycling different peptides offers one approach to maintaining sensitivity

This situation severely impairs oocyte development and quality, potentially contributing to the infertility commonly associated with endometriosis

Biochem Eng J 41(3):234240