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For individuals experiencing mild gastrointestinal upset from B12 supplements (uncommon but possible with high doses), taking the supplement with breakfast may improve tolerance

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Dat is de reden waarom zijn effect in studies ver buiten de grenzen van het gastro-intestinaal kanaal reikt, waar het oorspronkelijk werd ontdekt

10.1016/j.diabet.2016.03.008 [DOI] [PubMed] 52.Chapman LE, Darling AL, Brown JE (2015) The association between the biguanide drug metformin and vitamin B 12 deficiency in diabetic patients: a systematic review

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