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Arab J Urol (2018) 16(1):11324

Patients with pre-existing gastrointestinal conditionsinflammatory bowel disease, irritable bowel syndrome, or previous bowel surgeryshould maintain closer monitoring and lower thresholds for seeking medical input, as these populations may experience more pronounced or complex digestive effects

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If your results with tirzepatide have changed without any other explanation, discuss the possibility of medication degradation with your provider