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SURMOUNT-MAINTAIN (Horn 2026, 112 weeks): continued top dose -21.9% vs 5 mg step-down -16.6% vs placebo -9.9%, rescue therapy 8/25/67%: Aronne JAMA 2024

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The combination may be appropriate on training days, when it is important to maintain energy, concentration, and work intensity during exercise

Mechanistically, loss of the PUFA -oxidation enzyme 2,4-dienoyl-CoA reductase 1 increases cellular PUFA burden, elevates phospholipid hydroperoxides, and triggers ferroptotic death in cancer models 345

Hagen TM, Wierzbicka GT, Bowman BB, Aw TY, Jones DP