Mechanism of Action Nitric Oxide Synthase Pathway : L-citrulline works by converting to arginine through the urea cycle via argininosuccinate synthase and argininosuccinate lyase enzymes, then interacting with nitric oxide synthase (NOS) enzymes to generate nitric oxide and support the relaxation of blood vessel smooth muscle
[DOI] [PMC free article] [PubMed] [Google Scholar] 17.Ferrara N., Rinaldi B., Corbi G., Conti V., Stiuso P., Boccuti S., Rengo G., Rossi F., Filippelli A
Doyle C, Kushi LH, Byers T, Courneya KS, Demark-Wahnefried W, Grant B, McTiernan A, Rock CL, Thompson C, Gansler T, Andrews KS
Is that sustained release a serious legitimate risk of impacting/shutting off the pituitary and natural GH
Polasek et al., 2010