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One study systematically demonstrated the feasibility of probiotics and prebiotics regulating OP via the brain-gut-bone axis, particularly emphasizing the central roles of SCFAs, intestinal barrier repair, and immunomodulation, with their efficacy corroborated by both animal experiments and human clinical data (263)

Antioxidants 10:1442 Macvanin MT, Gluvic Z, Zafirovic S et al (2023) The protective role of nutritional antioxidants against oxidative stress in thyroid disorders