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To maintain homeostasis, organisms and cells developed a sophisticated enzymatic and non-enzymatic antioxidant defense system including catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) that counteracts excessive ROS levels

(Glutathione itself cannot be administered orally to patients because the body metabolizes it.) NAC is nearly 100% effective at saving lives and preventing liver damage but only if administered within eight hours of overdose

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Macmillan Publishers

Lu, X., Huang, L