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Many community frameworks discuss the combination as if it were interchangeable with either component alone in terms of effects

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doi: 10.1002/(SICI)1097-4547(19980901)53:5 3.0.CO;2-8 94 OrrCFRoweDBMizunoYMoriHHallidayGM

The advantage over direct GH is that secretagogues preserve natural pulsatile GH release patterns and work within physiological regulatory constraints