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doi: 10.1128/mBio.01941-17 99 DromerF.CharreireJ
[12] Threshold intake levels for adverse effects [edit] Adverse health and social effects associated with kava consumptionsuch as skin rashes, increased body mass index (BMI), elevated gamma-glutamyl transferase (GGT) enzyme levels, and higher lymphocyte countsmay begin to appear at intake levels of approximately 240 to 440 grams of kava powder per week, corresponding to 3,500 to 6,440 mg of kavalactones per day
Specifically, our meta-analysis demonstrated that blood GSSG, MDA, homocysteine, SAH, nitric oxide, and copper concentrations were significantly increased in children with ASD children relative to HC subjects
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