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The SELECT trial (Semaglutide Effects on Heart Disease and Stroke in Patients with Overweight or Obesity), completed in 2023 with over 17,600 participants, demonstrated a 20% reduction in major adverse cardiovascular events in patients with established cardiovascular disease and overweight or obesity but without diabetes

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TFPI2 suppresses the interaction of TGF-beta2 pathway regulators to promote endothelialmesenchymal transition in diabetic nephropathy

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