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This will facilitate the development of more targeted and effective management strategies, ensuring that interventions are optimally tailored to the metabolic and hepatic disease profiles of MASLD patients

Nat Cell Biol 3: 874882 Shi ZZ, OseiFrimpong J, Kala G, Kala SV, Barrios RJ, Habib GM, Lukin DJ, Danney CM, Matzuk MM, Lieberman MW (2000) Glutathione synthesis is essential for mouse development but not for cell growth in culture

H 2 O 2 produced during the oxidative folding of endoplasmic reticulum proteins has been found to regulate the signal transduction process of nuclear factor E2-related factor 2 (Nrf2), which in turn regulates the expression of downstream glutathione peroxidase 8 (GPX8), which in turn can participate in ER calcium regulation through endoplasmic reticulum calcium ATPase (SERCA) (Figure 7)

10.1016/j.psyneuen.2015.12.019 67