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Release of IL-1 and IL-18 was also decreased after CSE exposure, likely from a decreased amount of activated NLRP3 inflammasome complex, as evidenced by reduced levels of active caspase-1 (Fig

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While the Royal College of Physicians in the UK has declared vaping almost completely safe, and a definite improvement over smoking, the National Institute on Drug Abuse in the US focuses on the potential for harmful chemicals

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