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Lamhonwah AM, Tein I

In addition, the reduced activity of a key TCA cycle enzyme, isocitrate dehydrogenase 3 (IDH3), can cause lactate buildup and histone lactylation at sites like H4K12, H4K8, and H3K18

Still, stronger is not always better

150 mm x 2.1 mm 2.6 M 150 , Thermo Fisher Scientific) using a Vanquish Horizon UHPLC system (Thermo Fisher Scientific, Germering, Germany) coupled on-line to an Orbitrap Exploris 240 mass spectrometer (Thermo Fisher Scientific, Bremen, Germany) equipped with a HESI source

Water distribution depends primarily on the concentration of electrolytes in the body compartments and sodium (Na + ) plays a major role in maintaining physiologic equilibrium