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In parallel with MTXs most well-known targets, several NAD+-dependent enzymes were inhibited by the antifolate in vitro : 2-oxoglutarate, isocitrate, malate, pyruvate, succinate, 6-phosphogluconate and glucose-6-phosphate dehydrogenases, glutamate-cysteine ligase, glutathione reductase, and glutathione peroxidase (29)

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Fecal microbiota transplantation improves intestinal inflammation in mice with ulcerative colitis by modulating intestinal flora composition and down-regulating NF-kB signaling pathway

Studies demonstrate protection against diabetes, obesity, cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer through comprehensive metabolic optimization

2.2 Mechanism of ROS production within human sperm ROS are generated in two pathways: the extrinsic and the intrinsic pathway, described in Figure 1