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Even when tested for metabolic competency, the differences in the gene expression profiles compared to primary hepatocytes always raise concerns regarding the applicability of the investigated intracellular signaling mechanisms and the mode of cell death in humans

Acidic soil inhibits the functionality of arbuscular mycorrhizal fungi by reducing arbuscule formation in tomato roots

One characteristic example for this is the consequent cancer aggressiveness and bone metastasis of prostate cancer due to genetic loss of tumor suppressor PTEN and the Akt-induced aberrant accumulation of esterified cholesterol in lipid droplets [53, 80]

Targeting neutrophilse.g., via neutrophil elastase inhibitors or NET inhibitorsmay reduce inflammation and ferroptosis in COPD