While compelling evidence establishes ferroptosis as a key driver of cyst progression in ADPKDlinked to PKD1/PKD2 mutations, disrupted antioxidant networks (GPX4/SLC7A11), iron overload, and lipid peroxidationand validates ferroptosis modulators as potential therapeutics, several critical, insufficiently addressed research gaps persist
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BMJ Support Palliat Care 6:119121 Leinonen E, Skarstein J, Behnke K, Agren H, Helsdingen JT (1999) Efficacy and tolerability of mirtazapine versus citalopram: a double-blind, randomized study in patients with major depressive disorder
25 In experiments, it reduced liver damage caused by alcohol, heavy chemicals (like CCl), and even surgical stress
Evidence for individual bioregulator peptides in MS remains limited