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The researchers continue: In pernicious anemia [B12] absorption is impaired due to IF deficiency arising from autoimmune destruction of parietal cells

As awareness of B12 deficiency grows, many people consider supplementation options to restore healthy levels

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You may need B12 injections if you: Have been diagnosed with pernicious anemia Have gastrointestinal issues (e.g., Crohns disease, celiac disease, or after bariatric surgery) Follow a strict vegan or vegetarian diet without adequate supplementation Are over the age of 50, as absorption decreases with age Take certain medications that interfere with B12 absorption Have chronic fatigue, memory issues, or nerve problems due to B12 deficiency