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Immediate reactions to high-dose B12 Healthcare professionals typically use vitamin B12 amounts of 1,000 mcg and higher to treat a deficiency

Disadvantages involve higher long-term costs from continuous product consumption, possible adaptation reducing treatment responsiveness over time, psychological dependency on continuous application, and unknown very long-term effects from years of daily copper supplementation

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Some patients stay on GLP-1 medications long-term at maintenance doses

However, there may be some side effects associated with peptide-containing products