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High levels of lipid peroxidation-derived aldehydes, including 4-hydroxy-nonenal (4-HNE) and malondialdehyde (MDA) [92], protein glycoxidation markers such as pentosidine [93], and stress-induced DNA damage molecules, more specifically 8-hydroxy-2-deoxyguanosine (8-OHdG) [94, 95], have also been revealed in the spinal cord from sALS patients

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This solution based on simultaneous reduction and derivatization reaction shortened by 3 min the total time of sample preparation procedures, as well as reduced the amount of single-use polypropylene laboratory materials and laboratory wastes