Ultrasound gives the added advantage of targeting the surrounding tendons and muscles, which can be contributory to pain
This is a theoretical concern raised by the biology, not a demonstrated harm in humans for either compound, and it should be described as exactly that an unresolved question that the absence of long-term human data leaves open, not a proven risk and not a reason for false reassurance either
So, keeping an eye on B12 levels during chemo is key
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Another problem frequently encountered in the case of MS detectors is their susceptibility to the matrix effect, especially when the ESI ion source is used