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Creatine is one of the most widely studied supplements in the market right now

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A meta-analysis sits at the top of the evidence hierarchy because it combines data from multiple independent studies

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However, no significant changes in gut microbiota composition were detected ( 3.4.4.2 Prebiotics In a male rat model of PTSD-like symptoms induced via amygdala hyperactivation (a key pathophysiological mechanism of PTSD)3 weeks of treatment with the prebiotic GOS restored microbial homeostasis by enriching beneficial Bifidobacterium animalis and Limosilactobacillus reuteri , while eliminating harmful Enterococcus casseliflavus (Ruciski et al., 2025)