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many published studies involve laboratory models or animals rather than humans

Insulin-like growth factor-binding protein-3 modulates expression of Bax and Bcl-2 and potentiates p53-independent radiation-induced apoptosis in human breast cancer cells

Quantitative targeted-metabolite profiling can also be carried out to accurately quantify key metabolites in the metabolic pathways (such as -alanine metabolism, monoterpene biosynthesis, and glutathione metabolism pathways) significantly affected by melatonin treatment, using high-precision detection techniques such as liquid chromatography-tandem mass spectrometry

Cassetta L, Pollard JW