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Glutathione-responsive nanosystems are engineered to remain stable in circulation but undergo structural changes or drug release specifically in high-GSH tumor cells, improving therapeutic precision and reducing off-target toxicity

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Tirzepatide's development was predicated on the "incretin deficit" hypothesis in type 2 diabetes, wherein both GIP and GLP-1 responses are impaired

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M.ColucciL.BaudewynsD.BalkanJ.HuntT.HuntB.et al (2023)