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Prevention of inflammation-mediated neurotoxicity by Rg3 and its role in microglial activation

It has been reported that inflammation induced by direct injection of LPS can disrupt BBB and increase vascular permeability, increasing the infiltration of inflammatory mediators, leading to neuroinflammatory response and cognitive dysfunction (61) (Figure 2)

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Specifically, this included increased ( Egr, Nos, Srf, and Kras ) or decreased ( Egr, Vegfr, and Plc ) gene expression, while Akt1 gene expression remained unchanged (Vukojevic et al., 2018)

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