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Their results indicated a significant reduction in the frequency and duration of the migraine attacks, migraine days per month, and the amount of acute migraine medication (83)

Some mechanistic research relies on non-disease-specific models or tumor cell lines, and the applicability of their conclusions in clinical settings of autoimmune diseases remains to be verified

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A buildup of ROS such as H 2 O 2 (hydrogen peroxide) and O 2 - (superoxide anion) can lead to changes in metal homeostasis or oxidation states of protein metal complexes, such as the release of Fe from ferratin or the reduction of iron in cytochrome C [119]

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