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Description

In mice exposed to Gulf War agents, brain tissue showed evidence of mitochondria disturbances, with astroglia and microglia activation in the hippocampus with significant reductions in Cardiolipin (Abdullah et al., 2016), a strong indicator of decreased activity of the electron transport chain (Shen et al., 2015)

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Molecules 28(2):804

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At this stage, the disruption of macrophage polarization balance and fibroblast activation work together, pushing the tissue toward a turning point of inflammation self-limiting fibrosis immobilization. This marks the evolution of gout lesions from a functional inflammatory response to the irreversible stage of structural reconstruction

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