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RNA sequencing and pathway enrichment analysis show FOXO4-DRI significantly downregulates extracellular matrix-receptor interaction pathways, including fibronectin (Fn1), tenascin C (Tnc), and thrombospondin 2 (Thbs2), all critical components of fibrotic tissue architecture

Molecules 28 (8), 3630

The expensive medication could also weigh heavily on public health insurance programs, given that an estimated 6 million people in Japan have dementia