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To assess these hypotheses, a variety of senolytic drugs were tested in vitro (in a test tube) on BM-MSC from SLE patients and from lupus model (NZB/W) mice

it is an endogenous fragment, and one line of thinking holds that it may be liberated from larger proteins for example, during tissue injury when extracellular-matrix proteins such as collagen and SPARC (osteonectin) are proteolytically degraded

Plant Cell Physiol 52:894908 Ruan HH, Shen WB, Xu LL (2004) Nitric oxide involved in the abscisic acid induced proline accumulation in wheat seedling leaves under salt stress

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