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Concentrations naturally decline with age (from about 200 ng/mL at age 20 to 80 ng/mL by age 60), which is part of why supplementation makes sense

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( A ) Mean CellTiter-Glo measurements of A549shNRF2-BIND-luc, -BIND-WT NRF2, -BIND-Neh4/5mut cells treated with water (control) or 2.5 ng/mL dox for 48 h, then treated with indicated concentrations of BSO for 96 h

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In a comparative study of the herbicide oxadiazon, a xenobiotic with peroxisome proliferative activity but structurally distinct from other peroxisome proliferators, in Sprague-Dawley rats, CD1 mice, and Beagle dogs, treatment for fourteen (rats) or twenty-eight (mice and dogs) days produced liver enlargement in all three species (Richert et al