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Poznanski SM, Singh K, Ritchie TM, Aguiar JA, Fan IY, Portillo AL, Rojas EA, Vahedi F, El-Sayes A, Xing S, et al

Circulation 103, 25442549

utilizing a single eGFR value resulted in 8327 cases per 100,000 population, whereas a time-limited repeated eGFR-based definition resulted in 4637 cases per 100,000 population [4]

This pathway safely degrades homocysteinea potentially toxic byproduct of metabolisminto cysteine through two sequential enzymatic steps involving cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE)