Diagnostic test criteria for HLA genotyping to prevent drug hypersensitivity reactions: a systematic review of actionable HLA recommendations in CPIC and DPWG guidelines
Thaler FJ, Michalopoulos GK
Mechanism of Action (Step-wise) 1
As a fragment of growth hormone that specifically targets fat metabolism, it appears to avoid many of the side effects associated with full growth hormone therapy, such as joint pain, fluid retention, and effects on glucose metabolism
This heterodimer translocates to the nucleus, where HIF-1 binds the activating protein CREB ( P300 ) and the hypoxia reactive element ( HRE ), and subsequently initiates a series of hypoxia-induced cascades, including angiogenesis, through increased transcription of target genes, such as VEGF 28