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The in vivo tumor microenvironment involves complex interactions between cancer cells, stromal components, and the immune system, alongside fluctuating nutrient and oxygen gradients that were not fully captured in our models

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However, its propensity for rapid oxidation and deactivation largely limits the bioavailability

Results: The number of human genes associated with stem cell function was 57 genes in the range of increases of 50% UP and 46 genes in the range of decreases of 50% DOWN