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However, it should be noted that the association between aldose reductase, osmotic stress, oxidative stress, while very strong in the rat because of the high aldose reductase levels, is not supported by the various clinical trials with aldose reductase inhibitors

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MS (ES+) m/z 544.1.1H NMR (300 MHz, MeOD): H (ppm) 1.39 (s, 9H, BOC), 1.481.49 (m, 27H, 3xOtBu), 2.05 (t, 2H), 2.18 (m, 2H), 2.29 (m, 2H), 2.35 (t, 2H), 3.90 (dd, 1H,CH, 3J = 9.4 Hz, 3J = 4.27 Hz), 4.27 (dd, 1H,CH, 3J = 8.95 Hz, 3J = 5.29 Hz).13C NMR (75 MHz, MeOD):C (ppm) 26.48, 26.6, 27.1, 28.7, 30.43, 32.8, 52.97, 54.22, 79.87, 82.11, 156.58, 171.75, 173.1, 174.13

Functional plasticity of a peroxidase allows evolution of diverse disulfide-reducing pathways