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Constipation may first appear during this phase

At 10 percent concentration with the same application schedule, consumption rises to approximately 1.4 grams per month

10 ChakrabartyR.GraingerJ.GoebelC.BrookerL.GeorgeA

While Eli Lillys phase 2 trials reported side effects of mild-to-moderate gastrointestinal events, Poison Center data showed mounting cases of vomiting, fainting, rapid heart rate, and severe gastrointestinal distress

To support this metabolic process, some clinicians recommend co-supplementation with a methyl donor such as trimethylglycine (TMG) while on NAD+ injections