RA is primarily triggered by various factors, including an increase in acidic environment [105], abnormal levels of degrading enzymes [106] and the disorder of intracellular ROS [107]
Winther KH, Watt T, Bjrner JB, et al
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Therapeutic strategies aimed at targeting pathogenic antibody responses, such as intravenous immunoglobulin treatment, which is widely recognized for its anti-inflammatory and immunomodulatory effects, show promise in alleviating symptoms and enhancing patient outcomes [29,92,93,94,95,96,97]