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Although they primarily target joints, central nervous system, gastrointestinal tract, and multiple systemic organs, respectively, a common hallmark across these diseases is a significant disruption in the balance of T cell subsets, particularly a dynamic imbalance between Th17 cells and Treg cells ( Figure 2 )
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Another environmental factor which can be associated with neurotoxicity and adverse effects on the fetus in utero is air pollution, known to contain various airborne toxicants and contaminants capable of inducing oxidative stress and mitochondrial damage in vitro 34,35
