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The Alternatives Making an informed decision about regenerative therapies requires a clear-eyed comparison of their mechanisms, benefits, and limitations

The imidazole nitrogen of the histidine side chain donates one of the three nitrogen ligands to the copper, and the position of histidine at the second residue is what enables the deprotonated amide nitrogen of the preceding Gly-His peptide bond to also coordinate the copper

Tachycardia and hypertension may be controlled with propranolol (which also contains antiserotonergic properties)

Ongoing and future clinical studies are expected to provide deeper insights into its mechanisms of action and expand its therapeutic applications

(2015) 2:ofv004