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Author contributions XG was the chief investigator in charge of this trial program

Intracellular Activity: Unlike -MSH, which acts extracellularly, KPV enters cells and directly inhibits inflammatory signaling molecules within the nucleus

Due to its high solubility, amphipathic structure, and low molecular weight, melatonin displays a high intracellular and extracellular diffusion capacity, being able to cross cell membranes and the blood-brain barrier [6,15]

B12 and folate drive the methylation pathways behind dopamine and norepinephrine, so restoring them can sharpen focus and word recall

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