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Not surprisingly, PEGylation has emerged as the gold standard for engineering muco-penetrating LNPs for stability 161,162

However, treated of EACC with cis-platinum (apotosis agent) at 50 mM clearly induced the morphological changes characterized by reduction of cell volume (data not shown) and increased the DNA fragmentation to 7.25% of the control (Duthie et al., 1997)

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