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This dual functionality enables both stem cell pool expansion and directed differentiation depending on copper availability, providing remarkable versatility in regenerative applications

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[5] [6] Structure and function [edit] FOXO4 is a member of the forkhead family of transcription factors in O subclass, which is characterized by a winged helix domain used for DNA binding

10.1038/sj.gt.3302810 [DOI] [PubMed] [Google Scholar] Kokuzawa J., Yoshimura S., Kitajima H., Shinoda J., Kaku Y., Iwama T., et al

The rationale focuses on local gut effects rather than systemic distribution