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Limited long-term human safety data for most compounds, with evidence generally drawn from short trials, animal studies, or research on a different indication

Using expired b12 could certainly result in you not receiving the proper dosage due to deterioration as you now likely suspect given your setback

Introduction Cognitive decline may occur for a variety of reasons, including the accumulation of senescent cells, 1 excessive oxidative stress, 2 mitochondrial dysfunction, 3 loss of apoptosis, 4 environmental toxins 5,6 depletion of stem cells, 7 telomere shortening, 8 inefficient cell communication, 9 epigenetic alterations 10 and neuroinflammation

Long-term exposure to copper induces mitochondria-mediated apoptosis in mouse hearts