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GLP-1 agonists like semaglutide directly improve insulin sensitivity and reduce fasting insulin levels

Native amylin is co-secreted with insulin after meals and signals satiety, slows gastric emptying, and blunts post-meal glucagon

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To determine a more efficient method for hepatic specification and hepatocyte maturation, and to obtain highly homogeneous functional HLCs, two modified strategies were designed and evaluated (Fig