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Some orally administered drugs (eg, clonazepam, chlorpromazine, cyclosporine) are more extensively metabolized in the intestine than in the liver, while others (eg, midazolam) undergo significant (~ 50%) intestinal metabolism

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Another thing is the trials have to be long enough, both because it takes time to see the process of tissue damage play out, and also because we know from long trials of seed oils that short trials are useless

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