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The atypical behavior of fluorine compounds is unexpected in view of the large electronegativity difference between carbon and fluorine

It is part of why retatrutide is studied as a broader metabolic compound rather than only an appetite tool

PMID: 38656972

Together, our findings support that TGF 1 is driving BBB permeability via downregulation of claudin-5 and upregulation of MMP9 and that these effects are dependent on SMAD3