Thereafter, all cells were collected for quantitative analysis by flow cytometry (Invitrogen, Attune NxT, USA) and FlowJo 7.6.1
In addition, in vitro studies have shown that recombinant TTR amyloid aggregates are internalized by human cardiac fibroblasts, which subsequently secrete IL-6 and IL-8, providing mechanistic evidence that TTR aggregates can trigger inflammatory responses in cardiac cells [77]
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BPC-157 is not FDA-approved for any human use