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Vitamin B12 is a vital, water-soluble nutrient that your body cant produce on its ownit has to come from your diet

En condiciones de sobreexpresin de NNMT, esta reaccin consume nicotinamida (un precursor del NAD+) y agota reservas de SAM, alterando el equilibrio metablico celular

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Low NAD+ links to age-related diseases like cardiovascular issues, metabolic disorders, neurodegeneration, and cancer.[3][16] For example, in Alzheimer's models, NAD+ depletion exacerbates amyloid plaque formation and neuronal death