To avoid the need to replace entire stockpiles every few years at significant expense, and because it was recognized through testing that certain products remained stable beyond their labeled expiration dates when properly stored, the Shelf-Life Extension Program (SLEP) was established in 1986
The figure also shows that the selenium-dependent enzyme glutathione peroxidase oxidizes two molecules of glutathione back to GSSG while converting one molecule of hydrogen peroxide (H 2 O 2 ) into two molecules of water (H 2 O)
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For example, MarR is glutathionylated under oxidative conditions, 89 suggesting that other thiol-containing proteins, potentially including antibiotic targets or regulators, may also be modified in vivo
