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"Physiological control of metabolic flux: the requirement for multisite modulation"

Peripheral neuropathy: this is a condition that can cause damage to the nerves in the hands and feet, resulting in symptoms such as pain, numbness, and weakness

Figure 6 GH/IGF-1 in Insulin Sensitivity and Obesity The anti-insulin action of GH is very well established (173) as liver, skeletal muscle, and adipose tissue develop insulin resistance induced by GH administration (174177)

Science 289 , 21262128 (2000)

The relevance here is evidential, not procedural: because delivery and stability vary so much, comparing results across products and studies is genuinely difficult, and that heterogeneity is one reason a clean answer to the title question has been so slow to emerge