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An in-depth analysis of the molecular mechanisms of ferroptosis reveals multiple potential therapeutic targets and diverse regulatory pathways, providing directions for novel therapeutic strategies in kidney disease treatment

Bacterial metabolism also degrades plant polysaccharides and generates short-chain fatty acids that represent 10% of the calories absorbed daily by an individual [28]

The main mechanisms underlying ferroptosis include lipid peroxidation, GSH synthesis and consumption, and abnormal iron metabolism (Fig

Interestingly, the pH optimum of the enzyme detected in barley roots was reported to be higher than seven, which suggests that the activity could increase in conditions that induce alkalinisation of the apoplast (Ferretti et al., 2009)

The angiogenesis hypothesis may provide new insights by suggesting a decline in angiogenic growth factors with age, which in turn leads to a reduction in microcirculation in the body (Ambrose 2016)