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Generalized: Anaphylactic shock and death have been reported with administration of parenteral vitamin B 12(see WARNINGS)

The levels of proinflammatory cytokines (such as IL-1, IL-6, IL-8, IL-12p40, IFN-, TNF- and GM-CSF) are increased, while those of anti-inflammatory cytokines (such as IL-10 and TGF-) are decreased, in the blood of ASD patients